Compatibility «Мануэль 20» and «Фосапрепитант»
Between «Мануэль 20» and «Фосапрепитант» found 3 negative interactions, they should be taken with caution. the doctor may need to adjust the dosage.
Interaction tableCompare |
Фосапрепитант |
| ✘Мануэль 20 [Desogestrel+Ethinylestradiol and more 2Desogestrel, Ethinylestradiol] Analogs | |
| ✘Фосапрепитант [Fosaprepitant] Analogs |
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Interactions Мануэль 20 with Фосапрепитант
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Negative interactions
- With simultaneous administration of aprepitant in capsules of 100 mg 1 time per day for 14 days and an oral contraceptive containing 35 mcg of ethinyl estradiol and 1 mg of norethindrone, there was a decrease in the AUC of ethinyl estradiol by 43% and a decrease in the AUC of norethindrone by 8%.
- The effectiveness of hormonal contraceptives during the period of use and within 28 days after the end of the use of phosaprepitant may be reduced.
- In the study, the AUC of ethinyl estradiol decreased by 19% on day 10, and there was a decrease in Cmin ethinyl estradiol by 64% from days 9 to 21.
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Unclear interactions
- Oral contraceptives.
- In another study, a single oral contraceptive containing ethinyl estradiol and norethindrone, prescribed from days 1 to 21, was combined with simultaneous administration of an oral aprepitant according to the scheme - 125 mg on day 8 and 80 mg/day on days 9 and 10, ondansetron in a dose 32 mg IV on day 8 and dexamethasone, administered orally at a dose of 12 mg on day 8, and 8 mg / day on days 9, 10, 11.
- Hormonal contraceptives.
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Negative interactions
Decoding the colors of interactions and contraindications
| Dangerous | — | a pronounced negative interaction or contraindication. |
| Negative | — | negative interaction or side effect that may reduce effectiveness. |
| Positive | — | the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication. |
| No | — | the drugs do NOT interact, which is separately indicated in the instructions. |
| Unclear | — | the system failed to pre-assess the danger. |
Video instruction
Additional information
- Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
- Why do I need to
- Avoid dangerous prescriptions for your patients.
- Check the contraindications.
- Evaluate the safety of therapy in the treatment of children.
- See the compatibility of drugs with alcohol (enter it as a drug).
- Point the doctor to the found interaction - you may need to adjust the therapy.
- Do you need an API for interactions/drug analogues for your project? Write to us.
- The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
- The article is written: artificial intelligence Kiberis
- Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
- Total analyzed: 170,041,552 possible combinations of drugs and their components were found 412,577 interacting combinations.
- Medicine section: Standard evidence-based medicine
- The date of the last update of the interaction database: 2026-06-18
Category - medicine