Compatibility «Diclofenac» and «Diclofenac retard»

• Interactions Diclofenac with Diclofenac retard

  • Dangerous interactions
    • ⓘ Concomitant use of diclofenac and anticoagulants increases the risk of developing serious bleeding compared to using either of these medications alone..
    • ⓘ The simultaneous use of diclofenac and analgesic doses of acetylsalicylic acid is usually not recommended due to the increased risk of bleeding..
    • ⓘ When diclofenac is used concomitantly with ACE inhibitors or ARBs in elderly patients, those with hypovolemia, or those with impaired renal function, signs of deteriorating renal function should be monitored..
    • ⓘ Diclofenac, like other NSAIDs, may affect the synthesis of renal PGs and increase the toxicity of certain medications..
    • ⓘ Concomitant use of diclofenac and cyclosporine may enhance the nephrotoxicity of cyclosporine..
    • ⓘ Concomitant use of diclofenac with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of gastrointestinal toxicity with little or no increase in efficacy..
    • ⓘ Concomitant use of diclofenac with other NSAIDs or salicylates is not recommended..
    • ⓘ When diclofenac and pemetrexed are used concurrently in patients with impaired renal function (creatinine clearance 45–79 ml/min), it is necessary to monitor for signs of myelosuppression, renal toxicity, and gastrointestinal toxicity..
    • ⓘ NSAIDs with a short T_1/2 (e.g., diclofenac, indomethacin) should be avoided for two days before, on the day of, and for two days after taking pemetrexed..
  • Negative interactions
    • ⓘ Diclofenac is not a substitute for acetylsalicylic acid used in low doses to protect the cardiovascular system..
    • ⓘ When diclofenac is used concurrently with acetylsalicylic acid, its binding to plasma proteins decreases, although the clearance of the free NSAID remains unchanged..
    • ⓘ The clinical significance of this interaction is unknown; however, as with other NSAIDs, concomitant use of diclofenac and acetylsalicylic acid is generally not recommended due to the potential for increased side effects..
    • ⓘ When diclofenac is used concomitantly with ACE inhibitors, ARBs, or beta-blockers, blood pressure should be monitored..
    • ⓘ When diclofenac is used concurrently with diuretics, patients should be monitored for signs of impaired kidney function..
    • ⓘ It has been reported that the concurrent use of diclofenac and digoxin increases the concentration of digoxin in the blood serum and prolongs its T_1/2..
    • ⓘ When diclofenac is used concurrently with lithium-containing medications, patients should be monitored for signs of lithium toxicity..
    • ⓘ When diclofenac and methotrexate are used simultaneously, patients should be monitored for signs of methotrexate toxicity..
    • ⓘ When diclofenac and cyclosporine are used simultaneously, patients should be monitored for signs of impaired kidney function..
    • ⓘ Caution should be exercised when using diclofenac and cyclosporine simultaneously..
    • ⓘ The concomitant use of diclofenac and CYP2C9 inhibitors (for example, voriconazole increased the C_max and AUC of diclofenac by 114% and 78%, respectively) may enhance the effects and toxicity of diclofenac, whereas concomitant use with CYP2C9 inducers (for example, rifampicin) may reduce the effectiveness of diclofenac..
    • ⓘ Caution should be exercised when using diclofenac concurrently with CYP2C9 inhibitors or inducers; dose adjustment may be required..
    • ⓘ Concurrent use of diclofenac and pemetrexed may increase the risk of developing pemetrexed-associated myelosuppression, renal and gastrointestinal toxicity..
    • ⓘ Drugs: Diclofenac and Diclofenac retard there is common active substance : Diclofenac. Pay attention to the dosage..
  • Positive interactions
    • ⓘ Diclofenac and anticoagulants, such as warfarin, have a synergistic effect on bleeding..
  • Unclear interactions
    • ⓘ Patients who are concurrently taking diclofenac and anticoagulants (e.g., warfarin), antiplatelet agents (e.g., acetylsalicylic acid), SSRIs, and SNRIs should be monitored for signs of bleeding..
    • ⓘ Diclofenac is primarily metabolized with the involvement of CYP2C9..
    • ⓘ Diclofenac + Diclofenac retard analgin and citramon are used together in Diclofenac retard.
    • ⓘ Diclofenac + Diclofenac analgin and citramon are used together in Diclofenac.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

Video instruction

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,052,439 possible combinations of drugs and their components were found 412,588 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-10-22

Category - medicine