Compatibility «Kombinil-Duo» and «Ибупрофен+Парацетамол»

• Interactions Kombinil-Duo with Ибупрофен+Парацетамол

  • Dangerous interactions
    • ⓘ Ibuprofen (like other NSAIDs) should be used with caution in combination with acetylsalicylic acid or other NSAIDs and GCS due to an increased risk of adverse effects of this drug on the gastrointestinal tract.
    • ⓘ The combination of paracetamol with ethanol, GCS, corticotropin increases the risk of erosive and ulcerative lesions of the gastrointestinal tract.
    • ⓘ Reduce the therapeutic and toxic effects of barbiturates, phenytoin, rifampicin (accelerate metabolism), somatotropin, antacids (reduce absorption), enhance - estrogen-containing oral contraceptives, the risk of arrhythmias and hypokalemia - cardiac glycosides and diuretics, the likelihood of edema and hypertension - sodium-containing drugs or supplements, severe hypokalemia, heart failure and osteoporosis - amphotericin In and carbonic anhydrase inhibitors, the risk of erosive ulcerative lesions and bleeding from the gastrointestinal tract - NSAIDs.
    • ⓘ Prolonged simultaneous use of NSAIDs and GCS should be avoided due to an increased risk of adverse events from the gastrointestinal tract and impaired water-electrolyte balance.
    • ⓘ Inducers of microsomal liver enzymes or potentially hepatotoxic substances (for example, alcohol, rifampicin, isoniazid, hypnotics and antiepileptic drugs, including phenobarbital, phenytoin and carbamazepine) increase the toxicity of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, therefore liver function should be monitored.
    • ⓘ Increases the nephrotoxicity of cyclosporine, the risk of increased central nervous system excitability and convulsive reactions against the background of NSAIDs.
    • ⓘ The combination of very high doses of quinolones and NSAIDs (excluding acetylsalicylic acid) can provoke seizures; it should be used with caution.
    • ⓘ Quinolones (J01M)/ Fluoroquinolones (J01MA) + NSAIDs => Increased risk of central nervous system arousal and seizures.
    • ⓘ Animal studies show that NSAIDs can increase the risk of seizures associated with the use of quinolone antibiotics.
    • ⓘ Patients taking NSAIDs and quinolones may be at increased risk of seizures.
  • Negative interactions
    • ⓘ In addition, NSAIDs can mask fever, pain, swelling and other signs and symptoms of infection.
    • ⓘ Glucocorticoids (H02AB) + Amidopyrine, acetylsalicylic acid, butadione, indomethacin and other nonsteroidal anti-inflammatory drugs => Development of edema, increased damaging effect on the mucous membrane of the gastrointestinal tract.
    • ⓘ It enhances the side effects of mineralocorticoids, glucocorticoids, estrogens, ethanol.
    • ⓘ Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage with hepatotoxic drugs.
  • Unclear interactions
    • ⓘ НПВС.
    • ⓘ ГКС.
    • ⓘ Quinolone antibiotics.

Decoding the colors of interactions and contraindications

Dangerous	—	a pronounced negative interaction or contraindication.
Negative	—	negative interaction or side effect that may reduce effectiveness.
Positive	—	the interaction can SOMETIMES be used as a positive (often a dose adjustment is needed), or it is an indication.
No	—	the drugs do NOT interact, which is separately indicated in the instructions.
Unclear	—	the system failed to pre-assess the danger.

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Additional information

• Kiberis checks interactions and evaluates drug compatibility for free online right in the instructions thanks to the latest artificial intelligence technologies. The accuracy of finding is more than 95%, the accuracy of the hazard assessment is more than 80%. The online medical service takes into account all the drug groups of the selected drugs and all their components. And since the database contains 25,000 drugs with detailed instructions, not every pharmacologist can compete with our artificial intelligence. List of popular interactions.
• Why do I need to
  • Avoid dangerous prescriptions for your patients.
  • Check the contraindications.
  • Evaluate the safety of therapy in the treatment of children.
  • See the compatibility of drugs with alcohol (enter it as a drug).
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• The use of information about interactions is only possible as an introduction. This information should not be used to adjust therapy without consulting a specialist.
• The article is written: artificial intelligence Kiberis
• Sources: official instructions for medicines and their active substances, as well as inter-group interactions described in medical studies and textbooks.
• Total analyzed: 170,041,552 possible combinations of drugs and their components were found 412,577 interacting combinations.
• Medicine section: Standard evidence-based medicine
• The date of the last update of the interaction database: 2026-06-18

Category - medicine